It really depends on the engine efficiency and the application the engine is going to be run in., there is a different calculation for the type of racing, for instance a drag car that stays at wot, vs. a car that goes from off idle to wot., (turns). the object is to stay as close to the optimum air/fuel ratio for max power and still provide enough cooling from the fuel.. while maintaing a good fuel signal..
Read Burnillis (spelling) law.. A good example of this is it easier to suck thru a straw or a garden hose, or another way to look at it.. in a venturi when press. increase's, velocity decrease's. and vice/versa.. I know there is no such thing as suck... LOL..
Basically in most any circumstance on a kart, where you have turns, the carb is going to be most responsive and easier to turn with multiple throttle bores..
I'm pretty sure Jon, has done some t/b- venturi ratio calculations, I have, and it;s not just the size of the 360 carb, it's the t/b-venturi ratios.. in another words, you may be better with a 380 with stock throttle bore and 360 size ventures. they may flow the same, at wot, but flow different from off idle to wot.. another couple combos that have been tried, 360/380, 360c/360a., dual 33mm's with different t/b-venturi ratios, dual 34mm's with different t/b-venturi ratios..
Having a dyno is a good tool for for seeing this..
Do a search on carb theory, there are different calculations for different engines, type of racing, type of fuel., etc.. if I remember for gas, the multiplication factor is .85 for a engine that will be run with turns, and 1.1 for a drag car..