The below is copied from James at PRC about the Deuce. Hasn't steered me wrong yet.
The Deuce HAS TO HAVE more bite than most karts. 9 times out of 10 you cannot simply take the tires off of another kart, put them on a Deuce and expect it to run, ESPECIALLY if the set up is not right. You may be able to get away with it on a wet track with tires durometering in the 20's and 30's.
With Maxxis on a Recon, I used to wipe my tires 4-6 times per week and did very well. Now, with the Deuce at the same tracks (with relatively the same conditions), I wipe 10-15 times per week. Same prep as I've always used. Then, at the track I'm not doing anything different than normal. Wiping as needed, and choosing the right tires for the track conditions. I have won countless times on both karts, but there's no way I could prepare my tires for a Recon, put them on my Deuce and expect to be competitive.
As for set up... the Deuce cannot run more than 45.5% nose.
I've received many calls and messages with customers stating that their nose is 46.5-47.0% because "that's what they've always ran with other karts." Therein lies the problem. Different karts require different set ups, different tires, and sometimes different driving methods.
As for nose weight, mine has seemed to be best at 44.8%.
You also have to keep the left side weight lower on the Deuce than with recent karts. A lot of people have been getting away with 60.0% left and even up around 62.0% left with Recon & MINecon's. However, the Deuce will PUSH with that much left. I usually keep mine right around 60.0% in 425/super heavy, where I used to run 61.5% on my Recon.
Along with left, you cannot run up around 70.0% cross like many have over the years. Mine is normally around 64.5-65.5%.
So, for your normal, local track in stock medium/heavy you should have something like this:
Nose: 45.0%
Left: 58.5%
Cross: 65.0-66.0%
LF: Camber: +0.25 | Caster: 8 | Toe: 0
RF: Camber: -2.50 to -2.75 | Caster: 12 | Toe: 1/16" Out
Rear stagger will vary depending on track size and corner radius. We always run and recommend running 1-1/2" in the front.
If it doesn't turn (especially on entry) it's probably because it needs more bite.
I hope this helps anyone still working with their Deuce. Like I've said before, I LOVE mine!