I wouldn't use the Predator. The better question as others pointed out is the Tillotson vs Animal.
The Tillotson being based on the Honda GX200/Clone means the cost is lower for most of the components and because those platforms are far more common and less expensive. There are more companies, therefore competition, involved in continuing development of parts for that engine. That means more options for cylinder heads, valve train, carburetors, pistons, rods, crankshafts, etc and in many cases better than the Animal or Intek equivalent. It also means there will be newer part options in the future whereas the Animal and Intek is fairly stagnate.
Reliability is difficult to argue since it depends on how extreme the build, and the experience and technique of the builder. For example we have a regular dyno competition and in the 14.5ci open class, a Tillotson cast block engine made more power than a PPM all billet animal. Both engines ran big races like the Big O, Thanksgiving Thunder, Batesvilles, etc so they are not strictly dyno queens and have plenty of laps on them. The Tillotson may have required a lot of experience and a lot of work but if it wasn't push as hard it could still be a competitive engine while improving its reliability. For what it's worth, I believe at least two Tillotson cast blocks finish in the top 5 at the Big O this year.
For argument sake if the block reliability is in question or would have better rebuild intervals, then a billet block can be considered as well. The raised decks would allow longer rods to reduce rod angle for less piston wear, the longer rod would also help the rod ratio to slow the piston at TDC which reduces wrist pin flex and wear at the journal and top of the bore. The higher up front cost would pay off in the long run.
The most common failures from any engine is usually the valve train and less so the crankshaft. Out right block failure isn't common for either Tillotson or Animal unless something else failed first. I look at failures as an unavoidable part of racing, these are lawnmower engines we decided to turn 10,000rpms. I would look at the cost of rebuilding and cost of replacement since it is more predictable that reliability.
Another question would be, "what is your competition?" In our experience you may need less engine than you think. If you are competing against strong drivers with billet engines, you will have your work cut out for you. If you are running local events against all cast 212cc or 223cc engines, you're racing against guys on a budget. On that same idea, what is the best bang for your buck or what is your budget? That may also help decide which engine to build.