You seem to understand, if you're going to use a 400 tooth driver, and maintain the same ratio, let's say 4 – 1, then you would need a 1600 tooth "driven" on the axle.
It seems that, sometimes, in these gear ratio discussions, there are people talking about driver sprockets with no consideration for the driven sprockets. You've seen them, people talk about a 16 tooth driver giving you more top end, while a 14 tooth driver gives you more pull out of the corners. Although this would be true if you didn't change the axle sprocket, that's not what the discussion is about. There are times when I have trouble thinking about two things at the same time, maybe that has something to do with it.